The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans

E Camacho, R Vij, C Chrissian… - Journal of Biological …, 2019 - ASBMB
Melanins are synthesized macromolecules that are found in all biological kingdoms. These
pigments have a myriad of roles that range from microbial virulence to key components of …

Solid-state NMR reveals the carbon-based molecular architecture of Cryptococcus neoformans fungal eumelanins in the cell wall

S Chatterjee, R Prados-Rosales, B Itin… - Journal of Biological …, 2015 - ASBMB
Melanin pigments protect against both ionizing radiation and free radicals and have
potential soil remediation capabilities. Eumelanins produced by pathogenic Cryptococcus …

Microstructure of Cell Wall-Associated Melanin in the Human Pathogenic Fungus Cryptococcus neoformans

HC Eisenman, JD Nosanchuk, JBW Webber… - Biochemistry, 2005 - ACS Publications
Melanin is a virulence factor for many pathogenic fungal species, including Cryptococcus
neoformans. Melanin is deposited in the cell wall, and melanin isolated from this fungus …

Melanization of Cryptococcus neoformans in murine infection

JD Nosanchuk, P Valadon, M Feldmesser… - … and cellular biology, 1999 - Am Soc Microbiol
Cryptococcus neoformans is a fungus that is pathogenic in humans and that can produce
melanin in vitro. Melanization is associated with virulence, but there is no evidence that …

[HTML][HTML] Fungal melanin: what do we know about structure?

JD Nosanchuk, RE Stark, A Casadevall - Frontiers in microbiology, 2015 - frontiersin.org
The production of melanin significantly enhances the virulence of many important human
pathogenic fungi. Despite fungal melanin's importance in human disease, as well as …

Vesicle-associated melanization in Cryptococcus neoformans

HC Eisenman, S Frases, AM Nicola… - …, 2009 - microbiologyresearch.org
Recently, several pathogenic fungi were shown to produce extracellular vesicles that
contain various components associated with virulence. In the human pathogenic fungus …

Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility

C Chrissian, E Camacho, MS Fu… - Journal of Biological …, 2020 - ASBMB
Cryptococcus neoformans and Cryptococcus gattii are two species complexes in the large
fungal genus Cryptococcus and are responsible for potentially lethal disseminated …

Synthesis of Polymerized Melanin by Cryptococcus neoformans in Infected Rodents

AL Rosas, JD Nosanchuk, M Feldmesser… - Infection and …, 2000 - Am Soc Microbiol
The ability of Cryptococcus neoformans to synthesize polymerized melanin in vitro has been
associated with virulence, but it is unclear whether this fungus synthesizes polymerized …

Unlocking the Molecular Structure of Fungal Melanin Using 13C Biosynthetic Labeling and Solid-State NMR

S Tian, J Garcia-Rivera, B Yan, A Casadevall… - Biochemistry, 2003 - ACS Publications
Melanins are enigmatic pigments found in all biological kingdoms that are associated with a
variety of functions, including microbial virulence. Despite being ubiquitous in nature …

Melanin and virulence in Cryptococcus neoformans

A Casadevall, AL Rosas, JD Nosanchuk - Current opinion in microbiology, 2000 - Elsevier
Melanin synthesis has been associated with virulence for the human pathogenic fungus
Cryptococcus neoformans. Recent evidence indicates that C. neoformans cells synthesize …