[HTML][HTML] NNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T-cell epitope predictions
The set of peptides presented on a cell's surface by MHC molecules is known as the
immunopeptidome. Current mass spectrometry technologies allow for identification of large …
immunopeptidome. Current mass spectrometry technologies allow for identification of large …
Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data
B Reynisson, C Barra, S Kaabinejadian… - Journal of proteome …, 2020 - ACS Publications
Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …
Computational tools for the identification and interpretation of sequence motifs in immunopeptidomes
Recent advances in proteomics and mass‐spectrometry have widely expanded the
detectable peptide repertoire presented by major histocompatibility complex (MHC) …
detectable peptide repertoire presented by major histocompatibility complex (MHC) …
[HTML][HTML] NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets
M Nielsen, M Andreatta - Genome medicine, 2016 - Springer
Background Binding of peptides to MHC class I molecules (MHC-I) is essential for antigen
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand …
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where
they present peptides to T cells, which gives them a key role in the development of T-cell …
they present peptides to T cells, which gives them a key role in the development of T-cell …
NetMHCpan-4.0: improved peptide–MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data
Cytotoxic T cells are of central importance in the immune system's response to disease.
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
[HTML][HTML] Accurate MHC motif deconvolution of immunopeptidomics data reveals a significant contribution of DRB3, 4 and 5 to the total DR immunopeptidome
Mass spectrometry (MS) based immunopeptidomics is used in several biomedical
applications including neo-epitope discovery in oncology, next-generation vaccine …
applications including neo-epitope discovery in oncology, next-generation vaccine …
[PDF][PDF] MHCflurry 2.0: improved pan-allele prediction of MHC class I-presented peptides by incorporating antigen processing
Computational prediction of the peptides presented on major histocompatibility complex
(MHC) class I proteins is an important tool for studying T cell immunity. The data available to …
(MHC) class I proteins is an important tool for studying T cell immunity. The data available to …
[HTML][HTML] Predicting peptide presentation by major histocompatibility complex class I: an improved machine learning approach to the immunopeptidome
Background To further our understanding of immunopeptidomics, improved tools are
needed to identify peptides presented by major histocompatibility complex class I (MHC-I) …
needed to identify peptides presented by major histocompatibility complex class I (MHC-I) …
[HTML][HTML] Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes
W Zhao, X Sher - PLoS computational biology, 2018 - journals.plos.org
A number of machine learning-based predictors have been developed for identifying
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …