Regulation of glucocorticoid receptor (GR) levels is an important stress adaptation
mechanism. Transcription factor Nfgi-a and environmentally induced Gr promoter 17 …

Background: Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in
the regulation of physiological and behavioural responses to stress, the regulation of …

The unique variability in the 5′ region of the GR gene, with 9 alternative first exons and 13
splice variants plays a critical role in transcriptional control maintaining homeostasis of the …

Glucocorticoid receptor (GR) gene expression is regulated in a complex tissue-specific
manner, notably by early-life environmental events that program tissue GR levels. We have …

The level of expression of the glucocorticoid receptor (GR) is the principal determinant of
glucocorticoid sensitivity in most cells. GR levels are permanently 'set'in a tissue-specific …

Growing evidence suggests that early life stress (ELS) has long-lasting effects on
glucocorticoid receptor (GR) expression and behavior via epigenetic changes of the GR …

Glucocorticoid receptor (GR) promoter I 7 is susceptible to epigenetic changes induced by
environmental influences. Early life stress (ELS) has a persistent impact on GR expression …

Responding to different dynamic levels of stress is critical for mammalian survival. Disruption
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to …

Childhood trauma has been proposed to increase vulnerability to develop psychopathology
in part through an altered cortisol stress response. Research in rats has suggested that this …

The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …