Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating …

S Li, J Liu, S Liu, W Jiao, X Wang - Journal of Nanobiotechnology, 2021 - Springer
Objectives This study aimed to investigate the roles of adipose mesenchymal stem cell
(AMSC)-derived extracellular vesicles (EVs) binding with chitosan oligosaccharides (COS) …

[HTML][HTML] Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for …

J Zeng, P Sun, Y Zhao, X Fang, Z Wu, X Qi - Asian Journal of …, 2023 - Elsevier
Mesenchymal stem cells (MSC) are particularly effective in promoting cartilage regeneration
due to their immunomodulatory, anti-inflammatory and regenerative repair functions of …

Cartilage tissue engineering by co-transplantation of chondrocyte extracellular vesicles and mesenchymal stem cells, entrapped in chitosan–hyaluronic acid hydrogel

A Heirani-Tabasi, S Hosseinzadeh… - Biomedical …, 2021 - iopscience.iop.org
Mesenchymal stem cells (MSCs) on injectable hydrogels are mostly used to regenerate
articular cartilage, which would have a variety of outcomes. Chondrocyte extracellular …

Curcumin primed ADMSCs derived small extracellular vesicle exert enhanced protective effects on osteoarthritis by inhibiting oxidative stress and chondrocyte …

C Xu, Z Zhai, H Ying, L Lu, J Zhang, Y Zeng - Journal of …, 2022 - Springer
Osteoarthritis (OA) is a common joint disease caused by progressive articular cartilage
degeneration and destruction. Currently, there are no disease-modifying agents officially …

miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration

H Hu, L Dong, Z Bu, Y Shen, J Luo… - Journal of …, 2020 - Taylor & Francis
Articular cartilage has limited self-regenerative capacity and the therapeutic methods for
cartilage defects are still dissatisfactory in clinic. Recent studies showed that exosomes …

[HTML][HTML] Microvesicles from human adipose tissue-derived mesenchymal stem cells as a new protective strategy in osteoarthritic chondrocytes

M Tofiño-Vian, MI Guillén, MD Pérez del Caz… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Chronic inflammation contributes to cartilage degeneration during the
progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD …

Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel

S Li, Q Yuan, M Yang, X Long, J Sun, X Yuan… - … , Biology and Medicine, 2024 - Elsevier
Objective Osteoarthritis (OA) is characterized by progressive cartilage degeneration and
absence of curative therapies. Therefore, more efficient therapies are compellingly needed …

Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis

S Zhao, G Xiu, J Wang, Y Wen, J Lu, B Wu… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived
from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but …

Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy

K Ma, B Zhu, Z Wang, P Cai, M He, D Ye, G Yan… - Journal of …, 2020 - Springer
Background Umbilical cord mesenchymal stem cell (HUCMSC)-based therapies were
previously utilised for cartilage regeneration because of the chondrogenic potential of …

Cartilage regeneration using adipose-derived stem cells and the controlled-released hybrid microspheres

Y Han, Y Wei, S Wang, Y Song - Joint Bone Spine, 2010 - Elsevier
OBJECTIVE: This study was to evaluate the effect of hybrid microspheres (MS) composed of
gelatin transforming growth factor-beta (TGF-β1)-loaded MS and chitosan MS on the …