Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

Specification of primordial germ cells (PGCs) activates epigenetic reprogramming for
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …

Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …

Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …

Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …

Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …