Cell type-specific epigenetic links to schizophrenia risk in the brain
Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …
result from disturbances in early brain development. There is mounting evidence to support …
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …
Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits
LF Rizzardi, PF Hickey, A Idrizi, R Tryggvadóttir… - Genome biology, 2021 - Springer
Background DNA methylation dynamics in the brain are associated with normal
development and neuropsychiatric disease and differ across functionally distinct brain …
development and neuropsychiatric disease and differ across functionally distinct brain …
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
J Viana, E Hannon, E Dempster… - Human molecular …, 2017 - academic.oup.com
Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
Epigenetics in schizophrenia: a pilot study of global DNA methylation in different brain regions associated with higher cognitive functions
R Alelú-Paz, FJ Carmona, JV Sanchez-Mut… - Frontiers in …, 2016 - frontiersin.org
Attempts to discover genes that are involved in the pathogenesis of major psychiatric
disorders have been frustrating and often fruitless. Concern is building about the need to …
disorders have been frustrating and often fruitless. Concern is building about the need to …
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Schizophrenia is a severe psychiatric disease affecting about 1% of the world's population,
with significant effects on patients and society. Genetic studies have identified several …
with significant effects on patients and society. Genetic studies have identified several …
Characterization of cross-tissue genetic-epigenetic effects and their patterns in schizophrenia
Background One of the major challenges in current psychiatric epigenetic studies is the
tissue specificity of epigenetic changes since access to brain samples is limited. Peripheral …
tissue specificity of epigenetic changes since access to brain samples is limited. Peripheral …