Alcoholic liver disease (ALD) is typically associated with folate deficiency, which is the result
of reduced dietary folate intake, intestinal malabsorption, reduced liver uptake and storage …

Convincing evidence links aberrant B-vitamin dependent hepatic methionine metabolism to
the pathogenesis of alcoholic liver disease (ALD). This review focuses on the essential roles …

Emerging evidence indicates that ethanol-induced alterations in hepatic methionine
metabolism play a central role in the pathogenesis of alcoholic liver disease (ALD). Because …

This report is a summary of a symposium on the role of S-adenosylmethionine (SAM),
betaine, and folate in the treatment of alcoholic liver disease (ALD), which was organized by …

The goals and objectives of these studies, conducted over the past 30 y, were to determine:
a) how chronic alcoholism leads to folate deficiency and b) how folate deficiency contributes …

Methionine metabolism is regulated by folate, and both folate deficiency and abnormal
hepatic methionine metabolism are recognized features of alcoholic liver disease (ALD) …

Alcoholic liver disease is associated with abnormal hepatic methionine metabolism and
folate deficiency. Because folate is integral to the methionine cycle, its deficiency could …

Alcoholism is a major health problem in the United States and worldwide, and alcohol
remains the single most significant cause of liver-related diseases and deaths. Alcohol is …

Folates are members of the B‐class of vitamins, which are required for the synthesis of
purines and pyrimidines, and for the methylation of essential biological substances …

Alcoholic liver disease (ALD) is a global public health challenge due to the high incidence
and lack of effective therapeutics. Evidence from animal studies and ALD patients has …