After interaction with its receptor, GM-CSF induces phosphorylation of the β-chain in two
distinct domains in macrophages. One induces activation of mitogen-activated protein …

Type I interferons (IFN-I) activate STAT1, STAT2 and STAT3. While STAT1 and STAT2 play
positive roles in IFN-I-mediated antiviral responses, STAT3 negatively regulates the …

Histone deacetylase (HDAC) inhibition modulates dendritic cell (DC) functions and
regulates experimental graft-vs-host disease and other immune-mediated diseases. The …

Post‐translational modifications of histone proteins are major mechanisms that modify
chromatin structure and regulate gene expression in eukaryotes. Activation of histone …

It remains unclear how superantigen induces unresponsiveness in stimulated T cells. We
analyzed the chromatin status of the interleukin-2 (IL-2) promoter region in T cells stimulated …

We sought to determine if a specific class I and II HDAC inhibitor (ITF2357) was able to
decrease disease in lupus-prone NZB/W mice through regulation of T cell profiles. From 22 …

Signal transducer and activator of transcription 1 (STAT1) is important for innate and
adaptive immunity. Histone deacetylase inhibitors (HDACi) antagonize unbalanced immune …

APCs are critical in T cell activation and in the induction of T cell tolerance. Epigenetic
modifications of specific genes in the APC play a key role in this process, and among them …

Abstract pDC produce high levels of IFN-α and TNF-α upon TLR7/9 stimulation and express
high constitutive levels of the transcription factor IRF-7, which is required for IFN-α induction …