[HTML][HTML] Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

PS Rawat, A Jaiswal, A Khurana, JS Bhatti… - Biomedicine & …, 2021 - Elsevier
Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

Molecular mechanism of doxorubicin-induced cardiomyopathy–An update

K Renu, VG Abilash, TP PB, S Arunachalam - European journal of …, 2018 - Elsevier
Doxorubicin is utilized for anti-neoplastic treatment for several decades. The utility of this
drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the …

Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation

NF Sangweni, K Gabuza, B Huisamen, L Mabasa… - Archives of …, 2022 - Springer
A breakthrough in oncology research was the discovery of doxorubicin (Dox) in the 1960's.
Unlike other chemotherapy drugs, Dox was determined to have a greater therapeutic index …

Insights into doxorubicin-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring

N Wenningmann, M Knapp, A Ande, TR Vaidya… - Molecular …, 2019 - ASPET
Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of
cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity …

[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death

CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products

J Yu, C Wang, Q Kong, X Wu, JJ Lu, X Chen - Phytomedicine, 2018 - Elsevier
Background As an anthracycline antibiotic, doxorubicin (DOX) is one of the most potent and
widely used chemotherapeutic agents for various types of solid tumors. Unfortunately …

[PDF][PDF] Molecular mechanisms of cardiotoxicity: a review on major side-effect of doxorubicin

M Mobaraki, A Faraji, M Zare, P Dolati, M Ataei… - Indian J Pharm …, 2017 - academia.edu
Doxorubicin is among the most widely used drugs for the treatment of both adult and child
cancers. Doxorubicin is the major cause of chemotherapy-induced cardiotoxicity that is dose …

Doxorubicin-induced cardiotoxicity: causative factors and possible interventions

IC Jones, CR Dass - Journal of Pharmacy and Pharmacology, 2022 - academic.oup.com
Abstract Objectives Doxorubicin (Dox) belongs to the anthracycline drug classification and is
a widely administered chemotherapeutic. However, Dox use in therapy is limited by its …

[HTML][HTML] Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy

Y Chen, S Shi, Y Dai - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can
be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the …

Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches

M Sheibani, Y Azizi, M Shayan… - Cardiovascular …, 2022 - Springer
Doxorubicin is an effective chemotherapeutic agent prescribed to treat solid tumors (eg,
ovary, breast, and gastrointestinal cancers). This anti-cancer drug has various side effects …