Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression
SA Selamat, BS Chung, L Girard, W Zhang… - Genome …, 2012 - genome.cshlp.org
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …
most common histological subtype. Clinical and molecular evidence indicates that lung …
[HTML][HTML] Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
MM Bjaanæs, T Fleischer, AR Halvorsen, A Daunay… - Molecular …, 2016 - Elsevier
Background DNA methylation alterations are early events in tumorigenesis and important in
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …
Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer
YX Shi, Y Wang, X Li, W Zhang, HH Zhou, JY Yin… - BMC genomics, 2017 - Springer
Background Epigenetic alterations are strongly associated with the development of cancer.
The aim of this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) …
The aim of this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) …
Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome
Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA
methylation in gene promoter regions is a major mechanism of gene expression regulation …
methylation in gene promoter regions is a major mechanism of gene expression regulation …
[HTML][HTML] Genome-wide analysis of DNA methylation and the gene expression change in lung cancer
YJ Kwon, SJ Lee, JS Koh, SH Kim, HW Lee… - Journal of thoracic …, 2012 - Elsevier
Introduction The recent DNA methylation studies on cancers have revealed the necessity of
profiling an entire human genome and not to restrict the profiling to specific regions of the …
profiling an entire human genome and not to restrict the profiling to specific regions of the …
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
DS Shames, L Girard, B Gao, M Sato, CM Lewis… - PLoS …, 2006 - journals.plos.org
Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …
Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma
I Daugaard, D Dominguez, TE Kjeldsen… - Scientific reports, 2016 - nature.com
Lung cancer is the number one cause of cancer-related deaths worldwide. DNA methylation
is an epigenetic mechanism that regulates gene expression, and disease-specific …
is an epigenetic mechanism that regulates gene expression, and disease-specific …
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during
early carcinogenesis of lung adenocarcinoma has not been systematically studied. We …
early carcinogenesis of lung adenocarcinoma has not been systematically studied. We …
Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers
Smoking-associated DNA hypomethylation has been observed in blood cells and linked to
lung cancer risk. However, its cause and mechanistic relationship to lung cancer remain …
lung cancer risk. However, its cause and mechanistic relationship to lung cancer remain …
DNA methylome profiling of circulating tumor cells in lung cancer at single base-pair resolution
L Zhao, X Wu, J Zheng, D Dong - Oncogene, 2021 - nature.com
DNA methylation plays a pivotal role in regulating cellular processes, and altered DNA
methylation pattern is a general hallmark of cancer. However, DNA methylome in circulating …
methylation pattern is a general hallmark of cancer. However, DNA methylome in circulating …
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