The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …

Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …

Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein
1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for …

The decompaction and re-establishment of chromatin organization immediately after mitosis
is essential for genome regulation. Mechanisms underlying chromatin structure control in …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

The combinatorial action of co-localizing chromatin modifications and regulators determines
chromatin structure and function. However, identifying co-localizing chromatin features in a …

Enhancers and promoters predominantly interact within large-scale topologically
associating domains (TADs), which are formed by loop extrusion mediated by cohesin and …

Understanding the basic mechanisms underlying chromatin dynamics during DNA
replication in eukaryotic cells is of fundamental importance. Beyond DNA compaction …

CTCF and cohesin play a key role in organizing chromatin into topologically associating
domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change …

Active and inactive chromatin are spatially separated in the nucleus. In Hi-C data, this is
reflected by the formation of compartments, whose interactions form a characteristic …