The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

A subset of B cells with unique phenotypic and functional features—termed Age‐associated
B cells (ABCs)—has recently been identified in both mice and humans. These cells are …

Impaired humoral responses, as well as an increased propensity for autoimmunity, play an
important role in the development of immune system dysfunction associated with aging …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

Immune aging is a multi-faceted process that manifests as reduced competence to fight
infections and malignant cells, as well as diminished tissue repair, unprovoked …

Recent advances allow aging-associated changes in B-cell function to be approached at a
mechanistic level. Reduced expression of genes crucial to lineage commitment and …

Aging is considered to be an important risk factor for several inflammatory diseases. B cells
play a major role in chronic inflammatory diseases by antibody secretion, antigen …

Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

In this review we discuss the changes that occur in the B lymphocyte compartment of mice
and humans as they progress to old age, focusing on recent advances in this important area …

Age-associated B cells (ABCs) are formed under inflammatory conditions and are
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …