BACKGROUND The clinical success of the nucleoside analogs 5‐aza‐cytidine (5‐azaC)
and 5‐aza‐2′ deoxycytidine (5‐aza‐dC) as DNA methyltransferase (DNMT) inhibitors has …

Purpose Currently approved DNA hypomethylating nucleosides elicit their effects in part by
depleting DNA methyltransferase I (DNMT1). However, their low response rates and …

Estrogen Receptor‐β (ER‐β), a tumor‐suppressor in prostate cancer, is epigenetically
repressed by hypermethylation of its promoter. DNA‐methyltransferases (DNMTs), which …

Epigenetic changes, including aberrant DNA methylation, result in altered gene expression
and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) …

Background: Current therapeutic strategies for advanced prostate cancer (PCa) are largely
ineffective. Because aberrant DNA methylation associated with inappropriate gene-silencing …

Aberrant DNA methylation at the 5-position of cytosine, catalyzed by DNA
methyltransferases (DNMTs), is associated with not only various cancers by silencing of …

DNA methyltransferase inhibitors are widely used in preclinical and clinical studies, but poor
pharmacokinetics and low efficacy in solid tumors limit their therapeutic use. A new study …

Introduction: DNA methylation is an epigenetic modification that modulates gene expression
without altering the DNA base sequence. It plays a crucial role in cancer by silencing tumor …

ABSTRACT Introduction: DNA methyltransferases (DNMTs), important enzymes involved in
epigenetic regulation of gene expression, represent promising targets in cancer therapy …

Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent
anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the …