Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with∼
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides,. Most human gene promoters are …

The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of
most genes and often lack DNA methylation. Querying their apparent importance, the …

The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …

The mammalian genome is punctuated by CpG islands (CGIs), which differ sharply from the
bulk genome by being rich in G+ C and the dinucleotide CpG. CGIs often include …

One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more
than two-thirds of genes, whereas TATA boxes are only present at a minority of promoters …

The majority of mammalian gene promoters are encompassed within regions of the genome
called CpG islands that have an elevated level of non-methylated CpG dinucleotides …

DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …