Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated
with overactivation of the alternative pathway of complement. Four gain-of-function …

Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children.
Mutations in one or more genes encoding complement-regulatory proteins have been …

Several abnormalities in complement genes reportedly contribute to atypical hemolytic
uremic syndrome (aHUS), but incomplete penetrance suggests that additional factors are …

Complement is a major innate immune defense against pathogens, tightly regulated to
prevent host tissue damage. Atypical hemolytic uremic syndrome (aHUS) is characterized by …

Background: Genetic defects in complement proteins reportedly contribute to the atypical
hemolytic uremic syndrome (aHUS). Numerous genetic studies have been published in …

Atypical hemolytic uremic syndrome (aHUS) associates with complement dysregulation
caused by mutations and polymorphisms in complement activators and regulators. However …

Background Genetic variation in complement genes is a predisposing factor for atypical
hemolytic uremic syndrome (aHUS), a life-threatening thrombotic microangiopathy, however …

Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The
Global aHUS Registry collects real-world data on the natural history of the disease. Here we …

Atypical hemolytic uremic syndrome (aHUS) is a severe renal disorder that is associated
with mutations in genes encoding proteins of the alternative complement pathway …

Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure,
thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated …