[HTML][HTML] Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation

C Pilati, E Letouzé, JC Nault, S Imbeaud, A Boulai… - Cancer cell, 2014 - cell.com
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in
women using oral contraceptives. Here, exome sequencing identified recurrent somatic FRK …

Hepatocellular benign tumors—from molecular classification to personalized clinical care

JC Nault, P Bioulac–Sage, J Zucman–Rossi - Gastroenterology, 2013 - Elsevier
Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign
hepatocellular tumors that develop most frequently in women without cirrhosis. Genomic …

[HTML][HTML] Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesis

H Feng, ASL Cheng, DP Tsang, MS Li… - The Journal of …, 2011 - Am Soc Clin Investig
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. It is more
prevalent in men than women. Related to this, recent genetic studies have revealed a causal …

[PDF][PDF] Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

S Boyault, DS Rickman, A De Reyniès… - …, 2007 - Wiley Online Library
Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk
factors and genetic alterations. We further investigated transcriptome‐genotype‐phenotype …

Analysis of genomes and transcriptomes of hepatocellular carcinomas identifies mutations and gene expression changes in the transforming growth factor-β pathway

J Chen, S Zaidi, S Rao, JS Chen, L Phan, P Farci, X Su… - Gastroenterology, 2018 - Elsevier
Background & Aims Development of hepatocellular carcinoma (HCC) is associated with
alterations in the transforming growth factor-beta (TGF-β) signaling pathway, which …

Molecular classification of hepatocellular adenoma associates with risk factors, bleeding, and malignant transformation

JC Nault, G Couchy, C Balabaud, G Morcrette… - Gastroenterology, 2017 - Elsevier
Background & Aims Hepatocellular adenomas (HCAs) are benign liver tumors that can be
assigned to molecular subtypes based on inactivating mutations in hepatocyte nuclear factor …

Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma

S Rebouissou, P Bioulac-Sage, J Zucman-Rossi - Journal of hepatology, 2008 - Elsevier
Focal nodular hyperplasia (FNH) and hepatocellular adenomas (HCAs) are benign tumors
that occur in otherwise normal liver parenchyma. FNH is considered to be the result of a …

[HTML][HTML] Molecular genetics of hepatocellular neoplasia

S Jain, S Singhal, P Lee, R Xu - American journal of translational …, 2010 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading
cause of cancer deaths worldwide. Proper classification and early identification of HCC and …

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

M Eichenmüller, F Trippel, M Kreuder, A Beck… - Journal of …, 2014 - Elsevier
Background & Aims Hepatoblastoma (HB) is the most common childhood liver cancer and
occasionally presents with histological and clinical features reminiscent of hepatocellular …

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

K Schulze, S Imbeaud, E Letouzé, LB Alexandrov… - Nature …, 2015 - nature.com
Genomic analyses promise to improve tumor characterization to optimize personalized
treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of …