It has been suggested that cancer represents an alteration in DNA, heritable by progeny
cells, that leads to abnormally regulated expression of normal cellular genes; DNA …

The total genomic DNA methylation, ie, the percentage of methylated cytosines, was
measured in 20 cell lines derived from different types of human tumors. The measurements …

There is strong evidence that DNA methylation is not a neutral bystander in carcinogenesis,
but actively contributes to the process. Methylation of cytosine is known to promote mutation …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …

Changes in the pattern of DNA methylation have been a consistent finding in cancer cells.
The mostly descriptive nature of these studies and the fact that both hypo-and …

It is frequently assumed that DNA-damaging agents are carcinogenic because they induce
mutations. However, another strong possibility is that the damage leads to heritable changes …

Site-specific methylation of the human c-myc oncogene was investigated in a set of cultured
human tumor cell lines and normal human fibroblast strains. As previously reported, all of …

Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired
the ability to divide more rapidly than its normal counterparts (Nowell, PC (1976) Science …

The methylation state of DNA from human colon tissue displaying neoplastic growth was
determined by means of restriction endonuclease analysis. When compared to DNA from …

Although many carcinogens are mutagens, there is no direct evidence that the cancer-cell
phenotype is the result of gene mutation. Transplantation experiments have strongly …