Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy
TL Cvetkov, KW Huynh, MR Cohen… - Journal of Biological …, 2011 - ASBMB
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is
expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and …
expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and …
Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition
Pain, though serving the beneficial function of provoking a response to dangerous
situations, is an unpleasant sensory and emotional experience. Transient receptor potential …
situations, is an unpleasant sensory and emotional experience. Transient receptor potential …
Identification of in vivo disulfide conformation of TRPA1 ion channel
L Wang, TL Cvetkov, MR Chance… - Journal of Biological …, 2012 - ASBMB
TRPA1 (transient receptor potential ankyrin 1) is an ion channel expressed in the termini of
sensory neurons and is activated in response to a broad array of noxious exogenous and …
sensory neurons and is activated in response to a broad array of noxious exogenous and …
TRPA1: a molecular view
JE Meents, CI Ciotu… - Journal of …, 2019 - journals.physiology.org
The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing
neurons and other tissues and has become a major target in the development of novel …
neurons and other tissues and has become a major target in the development of novel …
[HTML][HTML] Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel
J Benedikt, A Samad, R Ettrich, J Teisinger… - … et Biophysica Acta (BBA …, 2009 - Elsevier
The ankyrin transient receptor potential channel TRPA1 is a sensory neuron-specific
channel that is gated by various proalgesic agents such as allyl isothiocyanate (AITC), deep …
channel that is gated by various proalgesic agents such as allyl isothiocyanate (AITC), deep …
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
L Zimova, V Sinica, A Kadkova, L Vyklicka, V Zima… - Science …, 2018 - science.org
Transient receptor potential ankyrin 1 (TRPA1) is a temperature-sensitive ion channel
activated by various pungent and irritant compounds that can produce pain in humans. Its …
activated by various pungent and irritant compounds that can produce pain in humans. Its …
Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein
N Banzawa, S Saito, T Imagawa, M Kashio… - Journal of Biological …, 2014 - ASBMB
The transient receptor potential ankyrin 1 (TRPA1) is a Ca 2+-permeable, nonselective
cation channel mainly expressed in a subset of nociceptive neurons. TRPA1 functions as a …
cation channel mainly expressed in a subset of nociceptive neurons. TRPA1 functions as a …
Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state
V Zíma, K Witschas, A Hynkova, L Zímová, I Barvík… - …, 2015 - Elsevier
The ankyrin transient receptor potential channel TRPA1 is a polymodal sensor for noxious
stimuli, and hence a promising target for treating chronic pain. This tetrameric six …
stimuli, and hence a promising target for treating chronic pain. This tetrameric six …
Trpa1
PM Zygmunt, ED Högestätt - … potential (TRP) cation channels: volume I, 2014 - Springer
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …
How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy
MSJ Brewster, R Gaudet - Bioessays, 2015 - Wiley Online Library
A new high‐resolution structure of a pain‐sensing ion channel, TRPA1, provides a
molecular scaffold to understand channel function. Unexpected structural features include a …
molecular scaffold to understand channel function. Unexpected structural features include a …