Abstract Cancer-associated fibroblasts (CAFs), a significant component of the tumor
microenvironment (TME), contribute to cancer progression through the secretion of …

Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

In recent years, research focused on the multifaceted landscape and functions of cancer-
associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities …

Increasing lines of evidence show that the malignant behavior of cancer is not exclusively
attributable to cancer cells but also radically influenced by cancerous stroma activity and …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer,
representing a group of heterogeneous cells. Many studies indicate that CAFs promote …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

The prognosis for patients with cancers known for a highly activated stromal reaction,
including diffuse‐type (scirrhous) gastric cancer, consensus molecular subtype 4 (CMS4) …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Stroma cells contribute to the microenvironment that is essential for cancer growth, invasion
and metastatic progression. Fibroblasts, often termed myofibroblasts or cancer-associated …