[HTML][HTML] SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways
H Yuan, Y Han, X Wang, N Li, Q Liu, Y Yin, H Wang… - Cancer cell, 2020 - cell.com
The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is
overexpressed in diverse carcinomas, including breast cancer. However, the molecular …
overexpressed in diverse carcinomas, including breast cancer. However, the molecular …
EZH2, an epigenetic driver of prostate cancer
YA Yang, J Yu - Protein & cell, 2013 - academic.oup.com
The histone methyltransferase EZH2 has been in the limelight of the field of cancer
epigenetics for a decade now since it was first discovered to exhibit an elevated expression …
epigenetics for a decade now since it was first discovered to exhibit an elevated expression …
[HTML][HTML] Regulation of EZH2 by SMYD2-mediated lysine methylation is implicated in tumorigenesis
Y Zeng, R Qiu, Y Yang, T Gao, Y Zheng, W Huang… - Cell reports, 2019 - cell.com
The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master
transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to …
transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to …
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1
Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
[HTML][HTML] Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability
SC Wu, Y Zhang - Journal of biological chemistry, 2011 - ASBMB
The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group
protein that plays important roles in many biological processes including cellular …
protein that plays important roles in many biological processes including cellular …
[HTML][HTML] Post-translational modifications of EZH2 in cancer
Z Li, M Li, D Wang, P Hou, X Chen, S Chu, D Chai… - Cell & bioscience, 2020 - Springer
Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive
Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 …
Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 …
Going beyond Polycomb: EZH2 functions in prostate cancer
Abstract The Polycomb group (PcG) protein Enhancer of Zeste Homolog 2 (EZH2) is one of
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …
[HTML][HTML] Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
L Gan, Y Yang, Q Li, Y Feng, T Liu, W Guo - Biomarker research, 2018 - Springer
Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …
Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
AV Ougolkov, VN Bilim, DD Billadeau - Clinical cancer research, 2008 - AACR
Purpose: Enhancer of zeste homologue 2 (EZH2), a histone methyltransferase, plays a key
role in transcriptional repression through chromatin remodeling. Our objectives were to …
role in transcriptional repression through chromatin remodeling. Our objectives were to …