Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis–What do we need to know?

J Herbert, PJ Lucassen - Frontiers in neuroendocrinology, 2016 - Elsevier
Depression (MDD) is prodromal to, and a component of, Alzheimer's disease (AD): it may
also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular …

Depression and Alzheimer's disease: is stress the initiating factor in a common neuropathological cascade?

S Aznar, GM Knudsen - Journal of Alzheimer's Disease, 2011 - content.iospress.com
The existence of a high co-morbidity between Alzheimer's disease (AD) and depression has
been known for a long time. More interesting though are recent studies indicating that …

Depression and risk of developing dementia

AL Byers, K Yaffe - Nature Reviews Neurology, 2011 - nature.com
Depression is highly common throughout the life course and dementia is common in late life.
Depression has been linked with dementia, and growing evidence implies that the timing of …

Depression—an underrecognized target for prevention of dementia in Alzheimer's disease

FS Dafsari, F Jessen - Translational Psychiatry, 2020 - nature.com
It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be
modifiable by the management of risk factors. While several recent guidelines and …

Depression in Alzheimer's disease: epidemiology, mechanisms, and management

S Chi, JT Yu, MS Tan, L Tan - Journal of Alzheimer's disease, 2014 - content.iospress.com
Depression occurs with a high prevalence of up to 50% in patients with Alzheimer's disease
(AD) and increases the caregivers' burden. Depression symptoms can precede clinical …

The association between late-life depression, mild cognitive impairment and dementia: is inflammation the missing link?

AP Hermida, WM McDonald, K Steenland… - Expert review of …, 2012 - Taylor & Francis
Depression, mild cognitive impairment (MCI) and dementia are highly prevalent conditions
that are increasing exponentially with similarly expanding social, medical and economic …

What is the association between depression and Alzheimer's disease?

N Tsuno, A Homma - Expert review of neurotherapeutics, 2009 - Taylor & Francis
Depression and dementia, in particular Alzheimer's disease (AD), are critically important
issues in the mental health of old age. Both conditions apparently reduce quality of life and …

Depression in dementia or dementia in depression? Systematic review of studies and hypotheses

A Brzezińska, J Bourke… - Current Alzheimer …, 2020 - ingentaconnect.com
The majority of research works to date suggest that Major Depressive Disorder (MDD) is a
risk factor for dementia and may predispose to cognitive decline in both early and late onset …

Depressive symptoms and mild cognitive impairment in the elderly: an ominous combination

DC Steffens - Biological psychiatry, 2012 - biologicalpsychiatryjournal.com
Both depression and mild cognitive impairment (MCI) are common conditions in older
adults, yet, until recently, little was known about their individual and conjoint influence on …

Chronic stress and A lzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia

A Milligan Armstrong, T Porter, H Quek… - Biological …, 2021 - Wiley Online Library
Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …