Epigenomic changes in DNA methylation patterns are evident in a variety of cancers,
including colorectal cancer (CRC). In addition, a large proportion of CRC tumors and cell …

Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for
maintenance of bulk DNA methylation and is essential for mouse development. However …

Abstract DNA methyltransferase 1 (DNMT1) is required to maintain DNA methylation
patterns in mammalian cells, and is thought to be the predominant maintenance …

DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is
responsible for maintaining the DNA methylation pattern during cell division. A long list of …

Alterations in DNA methylation have been associated with genome-wide hypomethylation
and regional de novo methylation in numerous cancers. De novo methylation is mediated by …

DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …

In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …

Alteration of DNA methylation is one of the most consistent epigenetic changes in human
cancers. DNA methyltransferase (DNMT) 1 is a major enzyme that determines genomic …

Abnormal methylation and associated silencing of tumor suppressor genes is a common
feature of many types of cancers. The observation of persistent methylation in human cancer …

Global hypomethylation of genes and repetitive sequences, as well as hypermethylation of
certain genes known to be involved in tumor suppression, are observed concurrently in …