Modern neuropathology serves a key function in the multidisciplinary management of brain
tumor patients. Owing to the recent advancements in molecular neurooncology, the …

Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …

For some, glioma biomarkers have been expected to solve common diagnostic problems in
routine neuropathology service caused by insufficient material, technical shortcomings or …

A number of key mutations that affect treatment and prognosis have been identified in
human gliomas. Two major ways to identify these mutations in a tumor sample are direct …

Significant progress has been made in the molecular diagnostic subtyping of brain tumors,
in particular gliomas. In contrast to the classical molecular markers in this field, p53 and …

The tumors classified as gliomas include a wide variety of histologies including the more
common (astrocytoma, glioblastoma), as well as the less common histologies …

Abstract The World Health Organization (WHO) classification system for glial tumors
provides guidance as to the predicted course of the disease and choice of treatment …

Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

The identification of distinct genetic and epigenetic profiles in different types of gliomas has
revealed novel diagnostic, prognostic, and predictive molecular biomarkers for refinement of …

This article reviews the histologic and molecular characterization of gliomas, including the
new “integrated diagnoses” of the World Health Organization Classification, 2016 edition …