Epigenome‐wide association studies in asthma: a systematic review
Objective Asthma is a common chronic respiratory airway disease influenced by
environmental factors and possibly their interaction with the human genome causing …
environmental factors and possibly their interaction with the human genome causing …
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
[HTML][HTML] Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study
Epigenome-wide studies of methylation in children support a role for epigenetic
mechanisms in asthma; however, studies in adults are rare and few have examined non …
mechanisms in asthma; however, studies in adults are rare and few have examined non …
[HTML][HTML] A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome
A Morin, EE Thompson, BA Helling… - Journal of Allergy and …, 2023 - Elsevier
Background DNA methylation of cytosines at CpG dinucleotides is a widespread epigenetic
mark; but genome-wide variation has been relatively unexplored due to the limited …
mark; but genome-wide variation has been relatively unexplored due to the limited …
[HTML][HTML] Epigenome-wide association study of asthma and wheeze in childhood and adolescence
Background Asthma heritability has only been partially explained by genetic variants and is
known to be sensitive to environmental factors, implicating epigenetic modifications such as …
known to be sensitive to environmental factors, implicating epigenetic modifications such as …
[HTML][HTML] Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma
Background Identifying novel epigenetic signatures associated with serum immunoglobulin
E (IgE) may improve our understanding of molecular mechanisms underlying asthma and …
E (IgE) may improve our understanding of molecular mechanisms underlying asthma and …
[HTML][HTML] Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium
C Qi, JM Vonk, DA van der Plaat… - Clinical and translational …, 2020 - Springer
Background Asthma is a chronic respiratory disease which is not curable, yet some patients
experience spontaneous remission. We hypothesized that epigenetic mechanisms may be …
experience spontaneous remission. We hypothesized that epigenetic mechanisms may be …
Expression quantitative trait methylation analysis reveals methylomic associations with gene expression in childhood asthma
Background Nasal (airway) epithelial methylation profiles have been associated with
asthma, but the effects of such profiles on expression of distant cis-genes are largely …
asthma, but the effects of such profiles on expression of distant cis-genes are largely …
DNA methylation biomarkers in asthma and rhinitis: are we there yet?
The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …
gene‐environment interactions and is providing new insights in the pathophysiology of …