Background Convection enhanced delivery (CED) infuses drugs directly into brain tissue.
Needle insertion is required and results in tissue damage which can promote flowback …

Flow back along a needle track (backflow) can be a problem during direct infusion, eg
convection-enhanced delivery (CED), of drugs into soft tissues such as brain. In this study …

Fluid flow back along the outer surface of a needle (backflow) can be a significant problem
during the direct infusion of drugs into brain tissues for procedures such as convection …

Phantoms are common substitutes for soft tissues in biomechanical research and are
usually tuned to match tissue properties using standard testing protocols at small strains …

Agarose hydrogels have been extensively used as a phantom material to mimic the
mechanical behavior of soft biological tissues, eg in studies aimed to analyze needle …

In this study, a distributed approach to account for dynamic friction during needle insertion in
soft tissue is presented. As is well known, friction is a complex nonlinear phenomenon. It …

A thorough understanding of needle–tissue interaction mechanics is necessary to optimize
needle design, achieve robotically needle steering, and establish surgical simulation …

Delivering therapeutic agents into the brain via convection-enhanced delivery (CED), a
mechanically controlled infusion method, provides an efficient approach to bypass the blood …

Convection-enhanced delivery (CED) is a rational technique for the direct intracranial
administration of a range of therapeutic agents. CED critically depends on the use of a …

The development of needles, needle–insertion simulators, and needle-wielding robots for
use in a clinical environment depends on a thorough understanding of the mechanics of …