Mutations in polycystin-1 and transient receptor potential polycystin 2 (TRPP2) account for
almost all clinically identified cases of autosomal dominant polycystic kidney disease …

The founding member of the TRPP family, TRPP2, was identified as one of the disease
genes causing autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most …

Mutations in PKD2 gene result in autosomal dominant polycystic kidney disease (ADPKD).
PKD2 encodes polycystin-2 (TRPP2), which is a homologue of transient receptor potential …

It has been exciting times since the identification of polycystic kidney disease 1 (PKD1) and
PKD2 as the genes mutated in autosomal dominant polycystic kidney disease (ADPKD) …

Polycystin complexes, or TRPP-PKD complexes, made of transient receptor potential
channel polycystin (TRPP) and polycystic kidney disease (PKD) proteins, play key roles in …

Abstract Polycystin-2 (PC2, TRPP2), the gene product of PKD2, whose mutations cause
autosomal dominant polycystic kidney disease (ADPKD), belongs to the superfamily of TRP …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD 1 or
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …

Mutations in TRPP2 (polycystin-2) cause autosomal dominant polycystic kidney disease
(ADPKD), a common genetic disorder characterized by progressive development of fluid …

Polycystin-2 is a member of the transient receptor potential (TRP) family of ion channels that
is mutated in autosomal dominant polycystic kidney disease. Although its function as a non …

The vast majority (∼ 99%) of all known cases of autosomal dominant polycystic kidney
disease (ADPKD) are caused by naturally occurring mutations in two separate, but …