The response to exercise training (trainability) has been shown to have a strong heritable
component. There is growing evidence suggesting that traits such as trainability do not only …

Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

DNA methylation is a covalent biochemical modification controlling chromatin structure and
gene expression. Exercise elicits gene expression changes that trigger structural and …

The adaptive response of skeletal muscle to exercise training is tightly controlled and
therefore requires transcriptional regulation. DNA methylation is an epigenetic mechanism …

Highlights•Exercise alters the gene expression pattern in multiple tissues.•Regular exercise
can modify the genome-wide DNA methylation pattern in humans.•Regular exercise could …

Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …

Epigenetics is the study of mitotically or meiotically heritable phenotypes that occur as a
result of modifications to DNA, thereby regulating gene expression independently of …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

Aim: DNA methylation programs gene expression and is involved in numerous biological
processes. Accumulating evidence supports transgenerational inheritance of DNA …

Changes in DNA methylation may represent an intermediate step between the environment
and human diseases. Little is known on whether behavioral risk factors may modify gene …