Wound healing in the skin is a complex physiological process that is a product of a cell state
transition from homeostasis to repair. Mechanical cues are increasingly being recognized as …

Human skin is a highly specialized mechanoresponsive interface separating our bodies
from the external environment. It must constantly adapt to dynamic physical cues ranging …

The epidermis has an essential function in creating a barrier against the external
environment to retain proper fluid balance and block the entry of pathogens. When damage …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Stringent spatiotemporal regulation of the wound healing process involving multiple cell
types is associated with epigenetic mechanisms of gene regulation, such as DNA …

Recent evidence suggests that mechanical forces can significantly impact the biologic
response to injury. Integrated mechanical and chemical signaling networks have been …

Epigenetic regulatory mechanisms are essential for maintaining skin homeostasis and aid in
the processes of wound healing. The nucleus co‐ordinates gene expression using …

Wound repair is a systematic biological program characterized by four overlapping phases:
hemostasis, inflammation, proliferation, and remodeling. Notwithstanding differences …

Wound healing results in the formation of scar tissue which can be associated with
functional impairment, psychological stress, and significant socioeconomic cost which …

Significance: Skin scarring poses a major biomedical burden for hundreds of millions of
patients annually. However, this burden could be mitigated by therapies that promote wound …