Abstract Background In Alzheimer's Disease (AD), about one-third of the risk genes
identified by GWAS encode proteins that function predominantly in the endocytic pathways …

Increasing evidence has pointed to that dysregulation of the endo‐lysosomal system is an
early cellular phenotype of pathogenesis for Alzheimer's disease (AD). Rab5, a small …

Endocytic alterations are one of the earliest changes to occur in Alzheimer's disease (AD),
and are hypothesized to be involved in the selective vulnerability of specific neuronal …

Genome-wide association studies have identified BIN1 (Bridging integrator 1) and RIN3
(Ras and Rab interactor 3) as genetic risk factors for late-onset Alzheimer's disease (LOAD) …

Alzheimer's disease (AD) is characterized by deposits of aggregated proteins. Accumulation
of aggregation‐prone proteins activates protein quality control mechanisms, such as the …

Abstract Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …

Abstract β-Amyloid precursor protein (APP) and its cleaved products are strongly implicated
in Alzheimer's disease (AD). Endosomes are highly active APP processing sites, and …

Ras-associated binding (Rab) proteins are small GTPases that regulate the trafficking of
membrane components during endocytosis and exocytosis including the release of …

The orphan nuclear receptor Nurr1 (also known as NR4A2) is critical for the development
and maintenance of midbrain dopaminergic neurons, and is associated with Parkinson's …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly, characterized by
neurofibrillary tangles (NFTs), senile plaques (SPs), and a progressive loss of neuronal cells …