DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
KK Wong - Cellular Oncology, 2020 - Springer
Background Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) is one of the
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …
most devastating cancer types with a 5-year survival rate of only 9%. PDAC is one of the …
Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression
J Gao, L Wang, J Xu, J Zheng, X Man, H Wu… - Journal of Experimental …, 2013 - Springer
Background Altered gene methylation, regulated by DNA methyltransferases (DNMT) 1, 3a
and 3b, contributes to tumorigenesis. However, the role of DNMT in pancreatic ductal …
and 3b, contributes to tumorigenesis. However, the role of DNMT in pancreatic ductal …
Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors
DNA methyltransferase I (DNMT1) is the major methyltransferase responsible for
methylating DNA and is overexpressed in many cancers. DNMT1 is also a therapeutic target …
methylating DNA and is overexpressed in many cancers. DNMT1 is also a therapeutic target …
Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma
JJ Zhang, Y Zhu, Y Zhu, JL Wu, WB Liang… - Clinical and …, 2012 - Springer
Introduction Epigenetic modifications play an important role in multistage carcinogenesis.
The role of the three functional DNA methyltransferases (DNMTs) in pancreatic …
The role of the three functional DNA methyltransferases (DNMTs) in pancreatic …
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
Aberrant DNA methylation has been shown to play an important role during multistage
carcinogenesis in various human organs. The aim of the present study was to evaluate the …
carcinogenesis in various human organs. The aim of the present study was to evaluate the …
DNMT1 inhibition reprograms pancreatic cancer stem cells via upregulation of the miR-17-92 cluster
Pancreatic ductal adenocarcinoma (PDAC) and other carcinomas are hierarchically
organized, with cancer stem cells (CSC) residing at the top of the hierarchy, where they drive …
organized, with cancer stem cells (CSC) residing at the top of the hierarchy, where they drive …
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer
J Yang, X Wei, Q Wu, Z Xu, D Gu… - Molecular …, 2011 - spandidos-publications.com
Abstract DNA methyltransferase (DNMT) 1, DNMT3A and DNMT3B, which affect promoter
CpG methylation status, play a significant role in cancer development. Little is known …
CpG methylation status, play a significant role in cancer development. Little is known …
DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy
J Zhang, C Yang, C Wu, W Cui, L Wang - Cancers, 2020 - mdpi.com
DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
[HTML][HTML] DNMT3A and DNMT3B in breast tumorigenesis and potential therapy
X Man, Q Li, B Wang, H Zhang, S Zhang… - Frontiers in cell and …, 2022 - frontiersin.org
Breast cancer has become a leading cause of cancer-related deaths in women worldwide.
DNA methylation has been revealed to play an enormously important role in the …
DNA methylation has been revealed to play an enormously important role in the …
Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer
Cancer is a leading cause of death worldwide. Aberrant promoter hypermethylation of CpG
islands associated with tumor suppressor genes can lead to transcriptional silencing and …
islands associated with tumor suppressor genes can lead to transcriptional silencing and …