IGFBP2: integrative hub of developmental and oncogenic signaling network
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as
an IGF system regulator, controlling the distribution, function, and activity of IGFs in the …
an IGF system regulator, controlling the distribution, function, and activity of IGFs in the …
[HTML][HTML] IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications
YW Lin, XF Weng, BL Huang, HP Guo… - American journal of …, 2021 - ncbi.nlm.nih.gov
Insulin-like growth factor binding protein-1 (IGFBP-1) belongs to the insulin-like growth factor
(IGF) system, which plays an indispensable role in normal growth and development, and in …
(IGF) system, which plays an indispensable role in normal growth and development, and in …
IGFBP2 potentiates nuclear EGFR–STAT3 signaling
Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that
has both extracellular and intracellular functions. Despite a clear causal role in cancer …
has both extracellular and intracellular functions. Despite a clear causal role in cancer …
IGFBP-3/IGFBP-3 receptor system as an anti-tumor and anti-metastatic signaling in cancer
Q Cai, M Dozmorov, Y Oh - Cells, 2020 - mdpi.com
Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …
IGFBP-2-taking the lead in growth, metabolism and cancer
SW Yau, WJ Azar, MA Sabin, GA Werther… - Journal of cell …, 2015 - Springer
The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and
transduced by various intracellular signal pathways is modulated by the IGF Binding …
transduced by various intracellular signal pathways is modulated by the IGF Binding …
IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells
WJ Azar, SHX Azar, S Higgins, JF Hu… - …, 2011 - academic.oup.com
IGF binding protein (IGFBP)-2 is one of the most significant genes in the signature of major
aggressive cancers. Previously, we have shown that IGFBP-2 enhances proliferation and …
aggressive cancers. Previously, we have shown that IGFBP-2 enhances proliferation and …
IGFBP-2: The dark horse in metabolism and cancer
VC Russo, WJ Azar, SW Yau, MA Sabin… - Cytokine & growth factor …, 2015 - Elsevier
The ubiquitous nature of the IGF system, expressed early in embryonic development
throughout postnatal and adult life, indicates a key role for this system in human biology …
throughout postnatal and adult life, indicates a key role for this system in human biology …
IGF‐independent effects of insulin‐like growth factor binding protein‐5 (Igfbp5) in vivo
G Tripathi, DAM Salih, AC Drozd… - The FASEB …, 2009 - Wiley Online Library
IGF activity is regulated tightly by a family of IGF binding proteins (IGFBPs). IGFBP‐5 is the
most conserved of these and is up‐regulated significantly during differentiation of several …
most conserved of these and is up‐regulated significantly during differentiation of several …
Insulin-like growth factor binding protein-3 (IGFBP-3): unraveling the role in mediating IGF-independent effects within the cell
S Varma Shrivastav, A Bhardwaj, KA Pathak… - Frontiers in cell and …, 2020 - frontiersin.org
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …
[HTML][HTML] Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers
Insulin-like growth factor-binding proteins (IGFBPs) are critical regulators of the mitogenic
activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special …
activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special …