Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as
an IGF system regulator, controlling the distribution, function, and activity of IGFs in the …

Insulin-like growth factor binding protein-1 (IGFBP-1) belongs to the insulin-like growth factor
(IGF) system, which plays an indispensable role in normal growth and development, and in …

Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that
has both extracellular and intracellular functions. Despite a clear causal role in cancer …

Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and
transduced by various intracellular signal pathways is modulated by the IGF Binding …

IGF binding protein (IGFBP)-2 is one of the most significant genes in the signature of major
aggressive cancers. Previously, we have shown that IGFBP-2 enhances proliferation and …

The ubiquitous nature of the IGF system, expressed early in embryonic development
throughout postnatal and adult life, indicates a key role for this system in human biology …

IGF activity is regulated tightly by a family of IGF binding proteins (IGFBPs). IGFBP‐5 is the
most conserved of these and is up‐regulated significantly during differentiation of several …

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …

Insulin-like growth factor-binding proteins (IGFBPs) are critical regulators of the mitogenic
activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special …