DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

DNA methylation is a major epigenetic modification that is strongly involved in the
physiological control of genome expression. DNA methylation patterns are largely modified …

Methylation of cytosines in cytosine–guanine (CpG) dinucleotides is one of the most
important epigenetic alterations in animals. The presence of methylcytosine in the promoter …

Cancer arises due to the accumulation of DNA modifications that give cells a selective
growth advantage. One common DNA modification is promoter hypermethylation associated …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

Background: DNA methylation is a highly characterized epigenetic modification of the
human genome that is implicated in cancer. The altered DNA methylation patterns found in …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …