Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Post-translational modifications and their implications in cancer

H Dutta, N Jain - Frontiers in Oncology, 2023 - frontiersin.org
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the
properties of a protein by covalently attaching a modified chemical group to some of its …

[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation

Y Geffen, S Anand, Y Akiyama, TM Yaron, Y Song… - Cell, 2023 - cell.com
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

Crosstalk of intracellular post-translational modifications in cancer

Z Wu, R Huang, L Yuan - Archives of biochemistry and biophysics, 2019 - Elsevier
Post-translational modifications (PTMs) have been reported to play pivotal roles in
numerous cellular biochemical and physiological processes. Multiple PTMs can influence …

Current methods of post-translational modification analysis and their applications in blood cancers

K Dunphy, P Dowling, D Bazou, P O'Gorman - Cancers, 2021 - mdpi.com
Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Posttranslational protein modifications: current implications for cancer detection, prevention, and therapeutics

KE Krueger, S Srivastava - Molecular & Cellular Proteomics, 2006 - ASBMB
Over the last several years major advances in sensitive high throughput technologies have
been made in the fields of genomics and proteomics. The hunt for diagnostic and prognostic …

Proteomics of post-translational modifications in colorectal cancer: Discovery of new biomarkers

G Zhu, L Jin, W Sun, S Wang, N Liu - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

Innovative chemical tools to address analytical challenges of protein phosphorylation and glycosylation

M Li, Y Xiong, G Qing - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Protein post-translational modifications (PTMs) modulate almost all cellular
processes. Aberrant PTMs are closely bound to various human diseases, which greatly …

Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease

TM Karve, AK Cheema - Journal of amino acids, 2011 - Wiley Online Library
Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …