Single-cell chromatin accessibility sequencing (scATAC-seq) reconstructs developmental
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

Recent technological advances have enabled massively parallel chromatin profiling with s
ingle-c ell A ssay for T ransposase A ccessible C hromatin by seq uencing (scATAC-seq) in …

Cellular function in tissue is dependent upon the local environment, requiring new methods
for spatial mapping of biomolecules and cells in the tissue context. The emergence of spatial …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …

Understanding complex tissues requires single-cell deconstruction of gene regulation with
precision and scale. Here, we assess the performance of a massively parallel droplet-based …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

INTRODUCTION During tissue turnover, stem and progenitor cells differentiate to produce
mature cell types. To understand and ultimately control differentiation, it is important to …

Abstract Development is a complex process that requires the precise modulation of
regulatory gene networks controlled through dynamic changes in the epigenome. Single …