Cellular commitment to a specific lineage is controlled by differential silencing of genes,
which in turn depends on epigenetic processes such as DNA methylation and histone …

The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

There is accumulating evidence that many chronic diseases such as type 2 diabetes and
coronary heart disease might originate during early life. This evidence gives rise to the …

In spite of improving life expectancy over the course of the previous century, the health of the
US population is now worsening. Recent increasing rates of type 2 diabetes, obesity and …

Background: Epigenetic mechanisms provide one potential explanation for how
environmental influences in early life cause long-term changes in chronic disease …

Epigenetics has major relevance to all disease processes; cardiovascular (CV) disease and
its related conditions are no exception. Epigenetics is defined as the study of heritable …

The rapid increase in the incidence of chronic non-communicable diseases over the past
two decades cannot be explained solely by genetic and adult lifestyle factors. There is now …

The dramatic increase in global prevalence of metabolic disease is inexplicable when
considering only environmental or only genetic factors, leading to the need to explore the …

Although a newer area for study, exciting new evidence identifies that epigenetic processes
are highly dynamic and respond to a myriad of environmental stimuli. Integrating chromatin …

A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …