The production of fully functional insulin-secreting cells to treat diabetes is a major goal of
regenerative medicine. In this article, I review progress towards this goal over the last 15 …

In the twenty‐first century, diabetic patients are likely to be one of the major beneficiaries
from the advancement of regenerative medicine through cellular therapies. Though the …

Type 1 and type 2 diabetes affect 150 million people worldwide. This is a result of the
incapacity of pancreatic beta cells to produce and secrete enough insulin. Transplantation of …

In both type 1 and type 2 diabetes, insufficient numbers of insulin-producing β cells are a
major cause of defective control of blood glucose and its complications. Accordingly …

One promising approach for the cure of diabetes is the replacement of lost insulin-
expressing β cells by cell or regenerative therapy. The recent development of an effective …

Despite intensive research, a treatment for diabetic patients that completely restores
normoglycemia for an indefinite period of time remains elusive. Although islet …

Beta-cell replacement is considered the optimal treatment for type 1 diabetes, however, it is
hindered by a shortage of human organ donors. Given the difficulty of expanding adult beta …

The discovery of insulin more than 90 years ago introduced a life‐saving treatment for
patients with type 1 diabetes, and since then, significant progress has been made in clinical …

The number of patients worldwide suffering from the chronic disease diabetes mellitus is
growing at an alarming rate. Insulin-secreting β-cells in the islet of Langerhans are damaged …

Pancreatic β-cell failure underlies type 1 diabetes; it also contributes in an essential way to
type 2 diabetes. β-Cell replacement is an important component of any cure for diabetes. The …