Epigenetics in Alzheimer's disease: perspective of DNA methylation
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …
understood, but over the past years, the involvement of epigenetic mechanisms in the …
Epigenetics: Recent advances and its role in the treatment of Alzheimer's disease
X Xiao, X Liu, B Jiao - Frontiers in Neurology, 2020 - frontiersin.org
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …
DNA methylation in the pathology of Alzheimer's disease: from gene to cognition
Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …
DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders
G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …
corresponding gene expression. During the developmental stage, embryonic stem cells …
Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
JAY Roubroeks, RG Smith… - Journal of …, 2017 - Wiley Online Library
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …
various neurodegenerative diseases. In this review, we discuss advances that have been …
[PDF][PDF] DNA methylation alterations in Alzheimer's disease
AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …
genetic backgrounds often present with heterogeneous pathologies has prompted the …
Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease
Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …
There is evidence for the contribution of environmental factors, whose effect may be …
DNA methylation in Alzheimer's disease: In brain and peripheral blood
X Wei, L Zhang, Y Zeng - Mechanisms of Ageing and Development, 2020 - Elsevier
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has
caused a major global health concern with the aging of the population. Recent studies have …
caused a major global health concern with the aging of the population. Recent studies have …
Opening up the DNA methylome of dementia
R Delgado-Morales, M Esteller - Molecular psychiatry, 2017 - nature.com
Dementia is a complex clinical condition characterized by several cognitive impairments that
interfere with patient independence in executing everyday tasks. Various neurodegenerative …
interfere with patient independence in executing everyday tasks. Various neurodegenerative …
DNA methylation, a hand behind neurodegenerative diseases
H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …