Diverse post-translational modifications of histone amino termini represent an important
epigenetic mechanism for the organisation of chromatin structure and the regulation of gene …

Histone methylation was first described more than 35 years ago, but its role has remained
enigmatic. Proposed functions range from transcriptional regulation to the higher-order …

Histone lysine methylation plays a fundamental role in chromatin organization and function.
This epigenetic mark is involved in many biological processes such as heterochromatin …

The rapid progress in deciphering the processes of covalent histone modifications has
broadened our understanding of transcriptional regulation. Histone lysine methylation, along …

Epigenetic mechanisms control eukaryotic development beyond DNA‐stored information.
There are several pathways, including histone tail modifications, histone variant …

The N termini of nucleosomal histone polypeptides are both highly accessible and
extensively modified by various chemical moieties. Interpreting the language of these …

Complex patterns of histone lysine methylation encode distinct functions within chromatin.
We previously reported that trimethylation of lysine 9 of histone H3 (H3K9) occurs at both …

Histone lysine methylation is regarded as a very stable modification with important functions
in epigenetic gene control and for organizing chromatin domains. While more robust …

Histone N-termini (tails) undergo diverse post-translational modifications, including
acetylation, phosphorylation, methylation, ubiquitination and ADP-ribosylation (van Holde …

The functional significance of mono-, di-, and trimethylation of lysine residues within histone
proteins remains unclear. Antibodies developed to selectively recognize each of these …