Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity

FB Mullauer, L van Bloois, JB Daalhuisen… - Anti-cancer …, 2011 - journals.lww.com
Betulinic acid (BetA) is a plant-derived pentacyclic triterpenoid with potent anticancer
capacity that targets the mitochondrial pathway of apoptosis. BetA has a broad efficacy in …

Betulinic acid: a natural product with anticancer activity

S Fulda - Molecular nutrition & food research, 2009 - Wiley Online Library
Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of
biological activities including potent antitumor properties. This anticancer activity has been …

Betulinic acid: a promising anticancer candidate.

DA Eiznhamer, ZQ Xu - IDrugs: the investigational drugs journal, 2004 - europepmc.org
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has demonstrated
selective cytotoxicity against a number of specific tumor types, a variety of infectious agents …

Betulinic acid, a natural compound with potent anticancer effects

FB Mullauer, JH Kessler, JP Medema - Anti-cancer drugs, 2010 - journals.lww.com
New therapies using novel mechanisms to induce tumor cell death are needed with plants
playing a crucial role as a source for potential anticancer compounds. One highly promising …

Targeting mitochondrial apoptosis by betulinic acid in human cancers

S Fulda, G Kroemer - Drug discovery today, 2009 - Elsevier
Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of
biological activities including potent antitumor properties. This anticancer activity has been …

Betulinic acid: recent advances in chemical modifications, effective delivery, and molecular mechanisms of a promising anticancer therapy

M Ali‐Seyed, I Jantan, K Vijayaraghavan… - Chemical biology & …, 2016 - Wiley Online Library
An important method of drug discovery is examination of diverse life forms, including
medicinal plants and natural products or bioactive compounds isolated from these sources …

Sensitization for anticancer drug-induced apoptosis by betulinic acid

S Fulda, KM Debatin - Neoplasia, 2005 - Elsevier
We previously described that betulinic acid (BetA), a naturally occurring pentacyclic
triterpenoid, induces apoptosis in tumor cells through the mitochondrial pathway. Here, for …

Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types

JH Kessler, FB Mullauer, GM de Roo, JP Medema - Cancer letters, 2007 - Elsevier
Betulinic acid (BA) is a widely available plant-derived triterpene with reported activity against
cancer cells of neuroectodermal origin and leukaemias. Treatment with BA was shown to …

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion

FB Mullauer, JH Kessler, JP Medema - Apoptosis, 2009 - Springer
Betulinic acid (BetA) is a plant-derived pentacyclic triterpenoid that exerts potent anti-cancer
effects in vitro and in vivo, but is non toxic to untransformed cells. In our previous study we …

Betulin is a potent anti-tumor agent that is enhanced by cholesterol

FB Mullauer, JH Kessler, JP Medema - PloS one, 2009 - journals.plos.org
Betulinic Acid (BetA) and its derivatives have been extensively studied in the past for their
anti-tumor effects, but relatively little is known about its precursor Betulin (BE). We found that …