The number of Americans with opioid use disorder (OUD) has steadily risen over the past 2
decades, now affecting roughly 2.7 million adults. 1 The number of drug overdose deaths …

The opioid epidemic was declared a national public health emergency on October 26, 2017,
and, although there have been some significant increases in federal funding and new …

Today's management of chronic pain presents a challenging clinical dilemma. Although
clinicians wish to relieve a patient's suffering, they must do so without undertreating the pain …

Opioids remain the drug of choice for the clinical management of moderate to severe pain.
However, in addition to their most effective analgesic actions, opioids also produce a sense …

In response to data evidencing sharp increases in opioid overdose rates and the need to
advise prescribing clinicians, the Centers for Disease Control (CDC) issued the 2016 CDC …

Summary of the Clinical Problem Within the context of the opioid crisis, improving care for
patients experiencing pain, from acute to chronic, has been the focus of multiple …

Chronic pain is recognized by the National Academy of Medicine (formerly Institute of
Medicine) as a highly prevalent disease occurring much more frequently than other chronic …

Long-term Opioid Therapy for Chronic Pain and the Risk of Opioid Addiction Page 1 Long-term
Opioid Therapy for Chronic Pain and the Risk of Opioid Addiction HARRISON J. BURGESS …

Summary of the Clinical Problem Death caused by drug overdose is a major problem in the
United States. In 2014, nearly 29 000 people died of opiate overdose. 1 Underlying this …

The increase in overdose deaths from prescription opioids and heroin in the United States
over the past 20 years is believed to have resulted from increases in prescription of opioids …