[HTML][HTML] Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Y Lin, J Xu, H Lan - Journal of hematology & oncology, 2019 - Springer
Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

[HTML][HTML] Targeting tumor-associated macrophages to synergize tumor immunotherapy

X Xiang, J Wang, D Lu, X Xu - Signal transduction and targeted therapy, 2021 - nature.com
The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …

Tumour-associated macrophages as treatment targets in oncology

A Mantovani, F Marchesi, A Malesci, L Laghi… - Nature reviews Clinical …, 2017 - nature.com
Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Tumor‐associated macrophages in immunotherapy

S Yan, G Wan - The FEBS Journal, 2021 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are essential components of the tumor
microenvironment involved in the progression and metastasis of cancer. They are intimately …

[HTML][HTML] Targeting tumor-associated macrophages in anti-cancer therapies: convincing the traitors to do the right thing

C Belgiovine, E Digifico, C Anfray, A Ummarino… - Journal of Clinical …, 2020 - mdpi.com
In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …

[HTML][HTML] Tumor-associated macrophages: a potential target for cancer therapy

Y Tan, M Wang, Y Zhang, S Ge, F Zhong, G Xia… - Frontiers in …, 2021 - frontiersin.org
Macrophages, an important class of innate immune cells that maintain body homeostasis
and ward off foreign pathogens, exhibit a high degree of plasticity and play a supportive role …

[HTML][HTML] Tumor-associated macrophages: An effective player of the tumor microenvironment

U Basak, T Sarkar, S Mukherjee… - Frontiers in …, 2023 - frontiersin.org
Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

[HTML][HTML] Tumor-associated macrophages in tumor immunity

Y Pan, Y Yu, X Wang, T Zhang - Frontiers in immunology, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …

[HTML][HTML] Tumor-associated macrophages: an accomplice in solid tumor progression

Y Chen, Y Song, W Du, L Gong, H Chang… - Journal of biomedical …, 2019 - Springer
In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …

[HTML][HTML] Current strategies to target tumor-associated-macrophages to improve anti-tumor immune responses

C Anfray, A Ummarino, F Torres Andon, P Allavena - Cells, 2019 - mdpi.com
Established evidence demonstrates that tumor-infiltrating myeloid cells promote rather than
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …