Detecting neuroendocrine prostate cancer through tissue-informed cell-free DNA methylation analysis
Purpose: Neuroendocrine prostate cancer (NEPC) is a resistance phenotype that emerges
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …
[HTML][HTML] Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation
GM Franceschini, O Quaini, K Mizuno, F Orlando… - Cancer discovery, 2024 - AACR
Castration-resistant prostate cancer (CRPC) is a heterogeneous disease associated with
phenotypic subtypes that drive therapy response and outcome differences. Histologic …
phenotypic subtypes that drive therapy response and outcome differences. Histologic …
[HTML][HTML] Genomic DNA methylation-derived algorithm enables accurate detection of malignant prostate tissues
E Aref-Eshghi, LC Schenkel, P Ainsworth, H Lin… - Frontiers in …, 2018 - frontiersin.org
Introduction The current methodology involving diagnosis of prostate cancer (PCa) relies on
the pathology examination of prostate needle biopsies, a method with high false negative …
the pathology examination of prostate needle biopsies, a method with high false negative …
[HTML][HTML] Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer
Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%–20%
of advanced treatment-resistant prostate cancers, and this may manifest clinically as …
of advanced treatment-resistant prostate cancers, and this may manifest clinically as …
[HTML][HTML] Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate …
T Dillinger, R Sheibani-Tezerji, W Pulverer, I Stelzer… - Molecular Cancer, 2022 - Springer
Prostate cancer (PCa) is among the most common cancers in men worldwide [1] and
comprises a highly heterogenous disease, which ranges from indolent localized cancer to …
comprises a highly heterogenous disease, which ranges from indolent localized cancer to …
Risk score predicts high‐grade prostate cancer in DNA‐methylation positive, histopathologically negative biopsies
BACKGROUND Prostate cancer (PCa) diagnosis is challenging because efforts for effective,
timely treatment of men with significant cancer typically result in over‐diagnosis and repeat …
timely treatment of men with significant cancer typically result in over‐diagnosis and repeat …
Development of castration resistant prostate cancer can be predicted by a DNA hypermethylation profile
JC Angulo, G Andrés, N Ashour… - The Journal of …, 2016 - Elsevier
Purpose Detection of DNA hypermethylation has emerged as a novel molecular biomarker
for prostate cancer diagnosis and evaluation of prognosis. We sought to define whether a …
for prostate cancer diagnosis and evaluation of prognosis. We sought to define whether a …
[HTML][HTML] Epigenetic analysis of circulating tumor DNA in localized and metastatic prostate cancer: evaluation of clinical biomarker potential
MT Bjerre, M Nørgaard, OH Larsen, SØ Jensen… - Cells, 2020 - mdpi.com
Novel and minimally-invasive prostate cancer (PCa)-specific biomarkers are needed to
improve diagnosis and risk stratification. Here, we investigated the biomarker potential in …
improve diagnosis and risk stratification. Here, we investigated the biomarker potential in …
Epigenomic alterations in localized and advanced prostate cancer
PC Lin, EG Giannopoulou, K Park, JM Mosquera… - Neoplasia, 2013 - Elsevier
Although prostate cancer (PCa) is the second leading cause of cancer death among men
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …
DNA methylation biomarkers of prostate cancer: Confirmation of candidates and evidence urine is the most sensitive body fluid for non‐invasive detection
SR Payne, J Serth, M Schostak, J Kamradt… - The …, 2009 - Wiley Online Library
BACKGROUND A prostate cancer (PCa) biomarker with improved specificity relative to PSA
is a public health priority. Hypermethylated DNA can be detected in body fluids from PCa …
is a public health priority. Hypermethylated DNA can be detected in body fluids from PCa …
相关搜索
- dna methylation prostate cancer
- epigenetic analysis prostate cancer
- tumor dna epigenetic analysis
- dna methylation noninvasive detection
- dna methylation risk score
- noninvasive detection prostate cancer
- risk score prostate cancer
- prostate tissues accurate detection
- biomarker potential prostate cancer
- liquid biopsies prostate cancer
- response evaluation prostate cancer
- body fluid prostate cancer
- tumor dna prostate cancer
- epigenomic alterations prostate cancer