Acceleration in the DNA methylation age in breast cancer tumours from very young women
Breast cancer in very young women (≤ 35 years; BCVY) presents more aggressive and
complex biological features than their older counterparts (BCO). Our aim was to evaluate …
complex biological features than their older counterparts (BCO). Our aim was to evaluate …
Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation
Age is a key risk factor for breast cancer and epigenetic alterations may contribute to age-
related increases in breast cancer risk, though the relation of age-related methylation in …
related increases in breast cancer risk, though the relation of age-related methylation in …
Accelerated aging in normal breast tissue of women with breast cancer
Background DNA methylation alterations have similar patterns in normal aging tissue and in
cancer. In this study, we investigated breast tissue-specific age-related DNA methylation …
cancer. In this study, we investigated breast tissue-specific age-related DNA methylation …
Age-related DNA methylation in paired normal and tumour breast tissue in Chinese breast cancer patients
Age-related DNA methylation is a potential mechanism contributing to breast cancer
development. Studies of primarily Caucasian women have identified many CpG sites of age …
development. Studies of primarily Caucasian women have identified many CpG sites of age …
[HTML][HTML] DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
S Ambatipudi, S Horvath, F Perrier, C Cuenin… - European journal of …, 2017 - Elsevier
Aim of the study A vast majority of human malignancies are associated with ageing, and age
is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …
is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …
Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes
M Rozenblit, E Hofstatter, Z Liu, T O'Meara… - Clinical …, 2022 - Springer
Purpose Age is one of the strongest risk factors for the development of breast cancer,
however, the underlying etiology linking age and breast cancer remains unclear. We have …
however, the underlying etiology linking age and breast cancer remains unclear. We have …
Increased epigenetic age in normal breast tissue from luminal breast cancer patients
Background Age is one of the most important risk factors for developing breast cancer.
However, age-related changes in normal breast tissue that potentially lead to breast cancer …
However, age-related changes in normal breast tissue that potentially lead to breast cancer …
Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age
KC Johnson, EA Houseman, JE King… - Breast cancer …, 2017 - Springer
Background The underlying biological mechanisms through which epidemiologically
defined breast cancer risk factors contribute to disease risk remain poorly understood …
defined breast cancer risk factors contribute to disease risk remain poorly understood …
DNA methylation age is elevated in breast tissue of healthy women
Background Limited evidence suggests that female breast tissue ages faster than other parts
of the body according to an epigenetic biomarker of aging known as the “epigenetic clock.” …
of the body according to an epigenetic biomarker of aging known as the “epigenetic clock.” …
Decelerated DNA methylation age predicts poor prognosis of breast cancer
JT Ren, MX Wang, Y Su, LY Tang, ZF Ren - BMC cancer, 2018 - Springer
Background DNA methylation (DNAm) age was found to be an indicator for all-cause
mortality, cancer incidence, and longevity, but no study has involved in the associations of …
mortality, cancer incidence, and longevity, but no study has involved in the associations of …