Folate is a nutrient essential for the development, function and regeneration of nervous
systems. Folate deficiency has been linked to many neurological disorders including neural …

Clinical studies suggest a relationship between folate deficiency and neurological and
disorders including Alzheimer's disease (AD). To investigate mechanisms underlying this …

The vitamin folic acid has been recognized as a crucial environmental factor for nervous
system development. From the early fetal stages of the formation of the presumptive spinal …

Background Folic acid supplementation reduces the risk of neural tube defects and
congenital heart defects. The biological mechanisms through which folate prevents birth …

Folate deficiency in a fetus is well known to cause neurodevelopment defects and
development disorders. A low level of folate is also thought to be a risk for depression in …

Folate deficiency and resultant increased homocysteine levels have been linked
experimentally and epidemiologically with neurodegenerative conditions like stroke and …

Folate is a nutrient crucial for rapidly growing tissues, including developing embryos and
cancer cells. Folate participates in the biosynthesis of nucleic acids, proteins, amino acids, S …

Highlights•Tissue-specific nutrient deficiencies occur without whole-body deficiencies in
disease.•The brain concentrates folate across the blood–brain barrier.•Blood–brain barrier …

Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of
homocysteine–a cytotoxic sulfur-containing amino acid that can induce DNA strand …

Despite the key role in neuronal development of a deficit in the methyl donor folate, little is
known on the underlying mechanisms. We therefore studied the consequences of folate …