Non-invasive prenatal diagnosis using cell-free fetal DNA technology: applications and implications

A Hall, A Bostanci, CF Wright - Public Health Genomics, 2010 - karger.com
Cell-free fetal DNA and RNA circulating in maternal blood can be used for the early non-
invasive prenatal diagnosis (NIPD) of an increasing number of genetic conditions, both for …

[HTML][HTML] Non-invasive prenatal diagnosis using cell-free fetal nucleic acids in maternal plasma: Progress overview beyond predictive and personalized diagnosis

G Tounta, A Kolialexi, N Papantoniou, GT Tsangaris… - EPMA Journal, 2011 - Springer
The discovery of circulating cell-free fetal DNA (cffDNA) in maternal plasma allowed for the
development of alternative methodologies that may facilitate safe non-invasive prenatal …

Uses of cell free fetal DNA in maternal circulation

M Hill, AN Barrett, H White, LS Chitty - Best practice & research Clinical …, 2012 - Elsevier
For over a decade, researchers have focused their attention on the development of non-
invasive prenatal diagnosis tests based on cell-free fetal DNA circulating in maternal blood …

Cell-free fetal DNA testing for prenatal diagnosis

S Drury, M Hill, LS Chitty - Advances in clinical chemistry, 2016 - Elsevier
Prenatal diagnosis and screening have undergone rapid development in recent years, with
advances in molecular technology driving the change. Noninvasive prenatal testing (NIPT) …

Best ethical practices for clinicians and laboratories in the provision of noninvasive prenatal testing

MA Allyse, LC Sayres, M Havard, JS King… - Prenatal …, 2013 - Wiley Online Library
Objective The goal of this study is to provide an ethical framework for clinicians and
companies providing noninvasive prenatal testing using cell‐free fetal DNA or whole fetal …

Delivering an accredited non‐invasive prenatal diagnosis service for monogenic disorders and recommendations for best practice

LA Jenkins, ZC Deans, C Lewis, S Allen - Prenatal Diagnosis, 2018 - Wiley Online Library
The identification of cell‐free fetal DNA circulating in maternal blood combined with
technological developments, in particular next‐generation sequencing, is enabling the …

Ethical and legal aspects of noninvasive prenatal genetic diagnosis

BM Dickens - International Journal of Gynecology & Obstetrics, 2014 - Wiley Online Library
The new technology that will allow genetic testing of a fetus within the first trimester of
pregnancy by isolating cell‐free fetal DNA (cffDNA) in the mother's blood raises a range of …

Toward an ethically sensitive implementation of noninvasive prenatal screening in the global context

J Mozersky, V Ravitsky, R Rapp, M Michie… - Hastings Center …, 2017 - Wiley Online Library
Noninvasive prenatal screening using cell‐free DNA, which analyzes placental DNA
circulating in maternal blood to provide information about fetal chromosomal disorders early …

Non invasive prenatal diagnosis of fetal aneuploidy using cell free fetal DNA

B Renga - European Journal of Obstetrics & Gynecology and …, 2018 - Elsevier
The discovery of cell free fetal DNA in maternal plasma has stimulated a rapid development
of non-invasive prenatal testing. The recent advent of massively parallel sequencing has …

Cell-free fetal nucleic acid testing: a review of the technology and its applications

LC Sayres, MK Cho - Obstetrical & gynecological survey, 2011 - journals.lww.com
Cell-free fetal nucleic acids circulating in the blood of pregnant women afford the opportunity
for early, noninvasive prenatal genetic testing. The predominance of admixed maternal …