The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Protein and DNA methylation have emerged as critical mechanisms for the control of
regulated gene transcription. In humans, the addition, recognition and removal of methyl …

DNA methylation is a class of epigenetic modification essential for coordinating gene
expression timing and magnitude throughout normal brain development and for proper brain …

Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Methylation of lysine and arginine residues on histones has long been known to determine
both chromatin structure and gene expression. In recent years, the methylation of non …

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-
based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future …

DNA methylation controls several cellular processes, from early development to old age,
including biological responses to endogenous or exogenous stimuli contributing to disease …

Changes to the epigenetic information within a cell play a significant role in cancer
development and progression. These epigenetic changes are important in establishing the …

Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes
with therapeutic relevance. Here we present a collection of chemical probes and associated …