Hypoxia-inducible factor (HIF)-1α is a transcription factor that regulates various genes
responding to hypoxic conditions. We previously reported that myeloid-specific activation of …

Background and aims We aimed to determine the effect of HIF-1α, the main regulatory
subunit of the hypoxia inducible factor 1 (HIF-1), on the development of the abdominal aortic …

Objective—Atherosclerotic lesions contain hypoxic areas, but the pathophysiological
importance of hypoxia is unknown. Hypoxia-inducible factor-1α (HIF-1α) is a key …

Objective Mural angiogenesis and macrophage accumulation are two pathologic hallmarks
of abdominal aortic aneurysm (AAA) disease. The heterodimeric transcription factor hypoxia …

Objective—The purpose of this study was to determine the role of smooth muscle cell–
derived hypoxia-inducible factor-1α (Hif-1α) in the pathogenesis of aortic aneurysms …

Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases,
including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous …

The process of vascular remodeling is associated with increased hypoxia. However, the
contribution of hypoxia-inducible factor 1α (HIF1α), the key transcription factor mediating …

Objective—We hypothesized that the hypoxia-inducible factor (HIF) 1α in vascular smooth
muscle contributes to the development of atherosclerosis, and links intravascular pressure to …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies
for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial …