Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability

J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future

E Dempster, J Viana, R Pidsley, J Mill - Schizophrenia bulletin, 2013 - academic.oup.com
Increased understanding about the functional complexity of the genome has led to growing
recognition about the role of epigenetic variation in the etiology of schizophrenia. Epigenetic …

Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers

B Khavari, MJ Cairns - Cells, 2020 - mdpi.com
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …

Epigenetic mediation of environmental influences in major psychotic disorders

BPF Rutten, J Mill - Schizophrenia bulletin, 2009 - academic.oup.com
The major psychotic disorders schizophrenia and bipolar disorder are etiologically complex
involving both heritable and nonheritable factors. The absence of consistently replicated …

Epigenetic mechanisms in schizophrenia

S Akbarian - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
Schizophrenia is a major psychiatric disorder that lacks a unifying neuropathology, while
currently available pharmacological treatments provide only limited benefits to many …

Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay

R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

L Smigielski, V Jagannath, W Rössler, S Walitza… - Molecular …, 2020 - nature.com
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy

B Swathy, M Banerjee - Epigenomics, 2017 - Taylor & Francis
The diatheses of gene and environment interaction in schizophrenia (SCZ) are becoming
increasingly evident. Genetic and epigenetic backgrounds are being considered in …

Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights

M Zamanpoor - Psychiatric genetics, 2020 - journals.lww.com
Schizophrenia is a common multigenic and debilitating neurological disorder characterized
by chronic psychotic symptoms and psychosocial impairment. Complex interactions of …

Genetics of schizophrenia: historical insights and prevailing evidence

J Van de Leemput, JL Hess, SJ Glatt, MT Tsuang - Advances in genetics, 2016 - Elsevier
Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …