Programmed methylation and demethylation of regulatory sequences has been proposed to
play a central role in vertebrate development. We report here that the methylation status of …

Nuclear transfer experiments have demonstrated that epigenetic mechanisms operate to
limit gene expression during animal development. In somatic cells, silenced genes are …

It has been nearly 40 y since it was suggested that genomic methylation patterns could be
transmitted via maintenance methylation during S phase and might play a role in the …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

The levels of genomic DNA methylation in vertebrate species display a wide range of
developmental dynamics. Here, we show that in contrast to mice, the paternal genome of the …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …