The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during
early carcinogenesis of lung adenocarcinoma has not been systematically studied. We …

Background Non-small cell lung carcinoma (NSCLC) is a complex malignancy that owing to
its heterogeneity and poor prognosis poses many challenges to diagnosis, prognosis and …

Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among
paired non-small cell lung cancers (NSCLC), we sought to profile DNA 5-methyl-cytosine …

Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …

Background DNA methylation alterations are early events in tumorigenesis and important in
the regulation of gene expression in cancer cells. Lung cancer patients have in general a …

Background: Aberrant DNA methylation occurs commonly during carcinogenesis and is of
clinical value in human cancers. However, knowledge of the impact of DNA methylation …

Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA
methylation in gene promoter regions is a major mechanism of gene expression regulation …

Background Epigenetic alterations are strongly associated with the development of cancer.
The aim of this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) …

Background DNA methylation is associated with aberrant gene expression in cancer, and
has been shown to correlate with therapeutic response and disease prognosis in some …

Lung cancer is the leading cause of cancer‐related death in men and women worldwide.
Owing to the scarcity of effective tools for early detection and therapy strategies, the 5‐year …